Google Trends and other IT fever charts rate Data Science among the most rapidly emerging and promising fields that expand around computer science. Although Data Science draws on content from established fields like artificial intelligence, statistics, databases, visualization and many more, industry is demanding for trained data scientists that no one seems able to deliver. This is due to the pace at which the field has expanded and the corresponding lack of curricula; the unique skill set, which is inherently multi-disciplinary; and the translation work (from the US web economy to other ecosystems) necessary to realize the recognized world-wide potential of applying analytics to all sorts of data. In this contribution we draw from our experiences in establishing an inter-disciplinary Data Science lab in order to highlight the challenges and potential remedies for Data Science in Europe. We discuss our role as academia in the light of the potential societal/economic impact as well as the challenges in organizational leadership tied to such inter-disciplinary work. Applied Data Science in Europe